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pentobarbital will lessen the level or effect of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some lower in fentanyl plasma concentrations, deficiency of efficacy or, maybe, advancement of the withdrawal syndrome in a very